Expression of GATA3 in breast tumor and its clinical significance
10.13315/j.cnki.cjcep.2015.07.002
- VernacularTitle:乳腺肿瘤组织中GATA3的表达及临床意义
- Author:
Kai CHENG
;
Xiaodie ZHOU
;
Bo YU
;
Hai WANG
;
Xiaojun ZHOU
;
Qunli SHI
- Publication Type:Journal Article
- Keywords:
breast neoplasm;
GATA3;
immunohistochemistry;
pathlogical diagnosis
- From:
Chinese Journal of Clinical and Experimental Pathology
2015;(7):725-728
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the expression of GATA3 in breast tumors and its clinical significance. Methods Immunohisto-chemistry EnVision method was used to detect the expression of GATA3 protein in 132 cases of breast malignant tumor tissue, 29 cases of breast benign tumor tissue, 35 cases of breast carcinoma adjacent tissue. Besides, the GATA3 expression level was compared with several clinicopathological parameters. Result (1) All the breast normal tissues expressed GATA3, while 77% of the breast cancer tissue were found to be GATA3 positive. (2) GATA3 did not expressed in diffuse large B cell lymphoma and spindle cell malignant tumor of breast. (3) In the triple negative breast cancer, the expression of GATA3 was lower than that of any other subtypes of breast carcinoma (χ2 =29. 354, P<0. 001). Conclusion The positive expression of GATA3 is correlated to classification and grade in breast tumor. Detection of the expression of this biological maker may provide a valuable marker for the differential diagnosis and prog-nostic of breast carcinoma.
