Clinicopathological features and prognostic factors of apocrine carcinoma of breast
10.13315/j.cnki.cjcep.2015.07.004
- VernacularTitle:乳腺伴大汗腺分化的癌临床病理特征及预后分析
- Author:
Xinli LIU
;
Congying YANG
;
Hao CHEN
- Publication Type:Journal Article
- Keywords:
breast neoplasm;
apocrine carcinoma;
axillary nodal metastasis;
hormone receptor
- From:
Chinese Journal of Clinical and Experimental Pathology
2015;(7):734-739
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the clinicopathologic features and prognostic factors of apocrine carcinoma ( AC) of breast. Meth-od Clinical data of 70 ACs and 283 invasive carcinomas, not otherwise specified were collected. Differences between the prognostic outcomes of the two groups were compared, and the relationship between clinicopathological characteristics and prognosis was also ana-lyzed. Results The mean age of the patients with AC (56. 17 ± 12. 41 years) was older than those with invasive carcinoma not other-wise specified (52. 77 ± 11. 07 years) (P=0. 039). The patients with AC had a lower frequency of axillary nodal metastasis, a lower frequency of ER and PR positivity comparing to invasive carcinoma not otherwise specified ( P<0. 05 ) . No significant differences in the overall survival (P=0. 221) and disease-free survival (P=0. 378) periods of the two groups were observed. Kaplan-Meier surviv-al analysis showed tumor size, lymph node metastasis, pathological stage, lymph node tissue infiltration were related with prognosis of patients with AC ( P<0. 05 ) . In multivariate analysis, lymph node metastasis was associated with a worse prognosis ( P<0. 05 ) . Conclusions Although AC and invasive carcinoma not otherwise specified have different clinicopathologic characteristics, the prog-noses of patients with these diseases are similar. Lymph node metastasis could be used as an independent factor for predicting the prog-nosis of patients with AC, early diagnosis and early treatment is the key to improve its prognosis.
