Correlation of clinicopathological features and prognosis in patients with colorectal cribriform comedo-type adenocarcinoma
10.13315/j.cnki.cjcep.2015.07.014
- VernacularTitle:结直肠筛状粉刺型腺癌的临床病理特征与预后的关系
- Author:
Lihua ZHANG
;
Xiaoyan CHEN
;
Chen WANG
;
Shunhua CHEN
;
Liyu CAO
- Publication Type:Journal Article
- Keywords:
colorectal neoplasm;
adenocarcinoma;
cribriform comedo-type;
metastasis
- From:
Chinese Journal of Clinical and Experimental Pathology
2015;(7):776-779
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the clinicopathological features and prognosis in patients with colorectal cribriform comedo-type ad-enocarcinoma. Methods Compared with 278 cases of colorectal common-type adenocarcinoma, 24 cases of colorectal cribriform come-do-type adenocarcinoma were analyzed for clinical stage, lymphovascular invasion, lymph node metastasis and genetic characteristics. Results The percentage of clinical Ⅲ and Ⅳ (87. 5%) and lymph node metastasis rate (87. 5%) in patients with colorectal cribri-form comedo-type adenocarcinoma was obviously higher than that in colorectal common-type adenocarcinoma (42. 4%,42. 4%) (P<0. 05). The percentage of lymphovascular invasion (87. 5%) of colorectal cribriform comedo-type adenocarcinoma were significantly higher than that of common-type adenocarcinoma (22. 7%) (P<0. 05). There were no statistical significance of age, sex, and molec-ular genetics of KRAS and mutated BRAF mutation between two groups ( P>0. 05 ) . Conclusions There is a higher clinical stage and poorer prognosis including unique morphological characteristics, highly lymphovascular invasion and lymph node metastasis in pa-tients with colorectal cribriform comedo-type adenocarcinoma.
