The Diagnostic Value of Combined Detection of Osteopontin and Matrix Metalloproteinase-9 for In-stent Restenosis in Patients After Percutaneous Coronary Intervention
10.3969/j.issn.1000-3614.2015.07.005
- VernacularTitle:骨桥蛋白和基质金属蛋白酶-9对经皮冠状动脉介入治疗后支架内再狭窄的诊断价值
- Author:
Hongwei YU
;
Qifeng LIU
;
Yuting WANG
;
Shan JIANG
- Publication Type:Journal Article
- Keywords:
Percutaneous coronary intervention;
In-stent restenosis;
Osteopontin;
Matrix Metalloproteinase-9;
Combined detection
- From:
Chinese Circulation Journal
2015;(7):635-638
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the diagnostic value of combined detection of blood osteopontin (OPN) and matrix metalloproteinase-9 (MMP-9) for in-stent restenosis (ISR) in patients after percutaneous coronary intervention (PCI). Methods: A total of 142 patients who received post-PCI coronary angiography (CAG) in our hospital were studied. The patients were divided into 2 groups based on if there were ISR condition: ISR group,n=21and Non-ISR group,n=121. The blood levels of OPN and MMP-9 were detected upon the follow-up CAG conduction and the basic clinical information with biochemical indexes were compared between 2 groups. Results: Blood levels of OPN and MMP-9 were signiifcantly higher in ISR group than those in Non-ISR group,P<0.001. Multivariate logistic regression analysis revealed that elevated levels of OPN and MMP-9 were the independent risk factors for post-PCI ISR occurrence (OR=2.861 and OR=3.343,P<0.01). The ROC area of OPN and MMP-9 for predicting post-PCI ISR occurrence were 0.821 and 0.887,P<0.001. Taking the optimal cut off value of OPN at 3.68 ng/ml and MMP-9 at 415.24 ng/ml, the combined detection could increase the sensitivity of detection (90.48%) and the negative predictive value (98.06%). Conclusion: Blood levels of OPN and MMP-9 are closely related to ISR occurrence in post-PCI patients, combined detection has certain predictive value for ISR occurrence, especially for negative predictive value.
