Relationship Between Lipid Control Level and In-stent Restenosis in Patients After Percutaneous Coronary Intervention
10.3969/j.issn.1000-3614.2015.07.007
- VernacularTitle:血脂控制水平与冠状动脉支架置入术后支架内再狭窄的相关性研究
- Author:
Cunrui ZHAO
;
Ming BAI
;
Bo ZHANG
;
Dong WANG
;
Yu PENG
;
Yan ZHANG
;
Jun PANG
;
Yan WANG
;
Zheng ZHANG
- Publication Type:Journal Article
- Keywords:
Blood lipids;
Percutaneous coronary intervention;
In-stent restenosis
- From:
Chinese Circulation Journal
2015;(7):644-646
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the relationship between lipid control level and in-stent restenosis (ISR) in patients after percutaneous coronary intervention (PCI). Methods: A total of 211 coronary artery disease (CAD) patients who received primary PCI in our hospital from 2012-01 to 2012-12 were studied. All the patients took oral dual anti-platelet therapy and statins routinely, and they received coronary angiography (CAG) re-examination at (3-12) months after PCI. According to CAG ifndings, the patients were divided into 2 groups: ISR group,n=25 and Non-ISR group,n=186. Blood levels of TC, TG, HDL-C, LDL-C were detected and compared before primary PCI and after CAG re-examination between 2 groups. Results: The baseline information such as age, gender, hypertension, family history of CAD, pre-operative diagnosis of coronary syndrome, smoking and drinking conditions were similar between 2 group,P>0.05; the pre-operative TC, TG, HDL-C, LDL-C were similar between 2 group,P>0.05. CAD patients combining with diabetes mellitus (DM) in ISR group (36.0%) was higher than that in Non-ISR group (17.7%),P=0. 03. Multivariate logistic regression analysis showed that at post PCI, no TC reduction (OR=1.07, 95% CI 0.38-2.62,P=0.04), LDL-C ≥ 1.8 mmol/L or the reduction less than 50% (OR=11.33, 95% CI 3.62-35.52,P<0.01), combining with DM (OR=3.00,95% CI 1.04-8.67,P=0.04) were positively related to ISR. Conclusion: Without TC reduction and nonstandard LDL-C level were the risk factors of ISR occurrence in CAD patients after PCI, DM complication may signiifcantly increase the risk of ISR.
