Association Study Between the rs4373814 Polymorphisms of Calcium Channel Gene and the Susceptibility of Essential Hypertension in Han Population at Northeastern Area of China
10.3969/j.issn.1000-3614.2015.07.012
- VernacularTitle:钙离子通道β2亚基基因rs4373814位点多态性与东北汉族人群原发性高血压易感性的关联研究
- Author:
Haiying ZHANG
;
Juanjuan SONG
;
Tianxiao LI
;
Yi WANG
;
Xinpeng LV
;
Hongbo ZHOU
;
Ying DENG
- Publication Type:Journal Article
- Keywords:
Essential hypertension;
Calcium Channel gene;
Single nucleotide polymorphism;
Association study
- From:
Chinese Circulation Journal
2015;(7):661-664
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the relationship between rs4373814 polymorphisms of calcium channel (CACNB2) gene and the susceptibility of essential hypertension (EH) occurrence in Han population at northeastern area of China. Methods: A case-control study in Han population at northeastern of China was carried out and the research included 1998 participants as 2 groups: EH group,n=1006 patients treated in our hospital, and Control group,n=992 subjects with normal blood pressure from physical examination. The rs4373814 polymorphisms were examined by Snapshot technique and the statistical analysis was performed by SPSS 19.0 software. Results: The rs4373814 risk allele C frequency of CACNB2 gene was signiifcantly different between EH group and Control group,P=0.039, OR=1.068, 95% CI (1.004-1.137). Logistic regression analysis showed that with adjusted gender, age, BMI, smoking, drinking, in dominant model, the genotype rs4373814 carring CC + GC/GG obviously increased the risk of EH occurrence,P=0.037, OR=1.260, 95% CI (1.013-1.567). Conclusion: The rs4373814 polymorphisms of CACNB2 gene are related to the susceptibility of EH occurrence in Han population at northeastern area of China.
