Angiotensin-(1-7)and tumors
10.3760/cma.j.issn.1673-422X.2015.04.009
- VernacularTitle:血管紧张素-（1-7）与肿瘤
- Author:
Lekang ZHAO
;
Jinming YU
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Angiotensin-(1-7)
- From:
Journal of International Oncology
2015;(4):274-276
- CountryChina
- Language:Chinese
-
Abstract:
Angiotensin-(1-7)[Ang-(1-7)]is an endogenous peptide-hormone of the renin-angioten-sin system. Ang-(1-7),angiotensin-converting enzyme 2( ACE2)and MAS receptor constitute ACE2-Ang-(1-7)-Mas axis,which antagonizes the ACE-AngⅡ-AngⅡ type 1 receptor axis. Recent studies indicate that Ang-(1-7)has certain effects on treating tumors,including inhibition of angiogenesis,anti-cell proliferation and inhibition of tumor fibrosis. Researches on the roles and mechanisms of Ang-(1-7)can provide new target for treatment and prevention of cancer.
