Ikaros and childhood acute lymphoblastic leukemia
10.3760/cma.j.issn.1673-422X.2015.04.021
- VernacularTitle:Ikaros 与儿童急性淋巴细胞白血病
- Author:
Lijun YI
;
Junkai DUAN
;
Hong LI
- Publication Type:Journal Article
- Keywords:
Transcription factor,Ikaros;
Leukemia;
Prognosis
- From:
Journal of International Oncology
2015;(4):316-318
- CountryChina
- Language:Chinese
-
Abstract:
Ikaros is a regulatory factor playing an important role in control of the development of hema-topoietic cells and immune system;and as a tumor suppressor,its aberration can cause both T and B lineage development arrest and neoplastic transformation,leading to insensitive to therapy and poor prognosis in actue lymphoblastic leukemia. Recently,researches on how Ikaros affects the leukemogenesis and prognosis become the focus of attention.
