Effect of Intravenous rhBNP on Regional Myocardium Deformability in Patients With Anterior Acute Myocardial Infarction After Primary Percutaneous Coronary Intervention
10.3969/j.issn.1000-3614.2015.07.009
- VernacularTitle:冻干重组人脑利钠肽对急性前壁心肌梗死患者直接经皮冠状动脉介入治疗术后局部心肌形变能力的影响
- Author:
Yating LIU
;
Yuhang WANG
;
Yanbo WANG
;
Miao SHI
;
Jianjun CHEN
;
Xinshun GU
- Publication Type:Journal Article
- Keywords:
Acute myocardial infarction;
Recombinant human brain natriuretic peptide;
Strain rate;
Regional left ventricular function;
Speckle tracking imaging
- From:
Chinese Circulation Journal
2015;(7):650-653
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the effect of intravenous recombinant human brain natriuretic peptide (rhBNP) on regional myocardium deformability in patients with anterior acute myocardial infarction (AMI) after primary percutaneous coronary intervention (PCI). Methods: A total of 35 patients with anterior AMI who received primary PCI within 12 hours of symptom onset in our hospital from 2013-06 to 2013-12 were enrolled in this study and randomized into 2 groups: rhBNP group, the patients received intravenous rhBNP,n=18, Control group, the patients received standard intravenous nitrates,n=17, and the intravenous pumping administration maintained for 72 hours in both groups. The echocardiography was conducted at immediately, 7 days and 1 month after PCI respectively to compare the relative parameters. The occurrence of major adverse cardiac events (MACE) were followed-up for 6 months in all patients. Results: The baseline condition was similar between the two groups,P>0.05 , the parameters of echocardiography as LVEF and WMSI at immediately and 7 days after PCI were similar between the two groups,P>0.05. Compared with Control group, rhBNP group had the increased LVEF and decreased WMSI at 1 month after PCI ,P<0.05; rhBNP group had increased SRs at 7 days after PCI,P<0.05, while SRe and SRa were similar between the two groups,P>0.05; SRs, SEe and Sra were increased at 1 month after PCI, allP<0.05. The cTnI value in rhBNP group was lower than that in Control group as (50.09 ± 16.88) ng/ml vs (63.24 ± 18.60) ng/ml,P=0.036. The occurrence of MACE was similar between the two group,P>0.05. Conclusion: Intravenous administration of rhBNP could improve the regional myocardium deformability and the systolic/diastolic function in patients with anterior AMI after primary PCI.
