COX-2 and its inhibitors in lung cancer drug resistance
10.3760/cma.j.issn.1673-422X.2015.03.011
- VernacularTitle:环氧合酶-2及其抑制剂与肺癌耐药的研究进展
- Author:
Hui HAN
;
Qing ZHANG
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Drug resistance;
Cyclooxygenase-2 inhibitors
- From:
Journal of International Oncology
2015;(3):203-205
- CountryChina
- Language:Chinese
-
Abstract:
COX-2 is the inducible form of cyclooxygenase,which is overexpressed in non-small cell lung cancer,especially in the adenocarcinoma,and is involved in the production of lung cancer drug resistance, reducing the sensitivities of tumor cells to chemotherapy drugs. COX-2 inhibitors have the effects of antitumor and prevention of tumor formation. Therefore,in order to reverse the drug resistance of tumor cells,improve the sur-vival rate and the prognosis of patients with tumor,the application of COX-2 inhibitors as adjuvant chemotherapy and combined with chemotherapy drugs has become a new direction in the treatment of lung cancer.
