The research progress of CD44 and anti-leukemia effect
10.3760/cma.j.issn.1673-422X.2015.03.020
- VernacularTitle:C D44与抗白血病效应的研究进展
- Author:
Yuan WANG
;
Xiaohan GAO
;
Hongling HAO
- Publication Type:Journal Article
- Keywords:
Leukemia;
CD44
- From:
Journal of International Oncology
2015;(3):235-237
- CountryChina
- Language:Chinese
-
Abstract:
Leukemia is a kind of cloning disease from malignant hematopoietic stem cells. Its patho-genesis may have relationship with proliferation out of control,dysdiffreentiation and inhibition of apoptosis about leukemia cells. The study confirms that CD44 is expressed in leukemia cells,promoting the occurrence and development of leukemia through participation in cell adhension,proliferation,migration and invasion behavior. In vitro experiment shows that CD44 targeted therapies can effectively kill leukemia cells,and reduce the toxicity to normal tissue cells. Therefore,aiming at the design of the anticancer drugs targeted for CD44 is expected to be used in clinical treatment of leukemia.
