Application value of combined detection of PG and FAS in diagnosis of gastric cancer
10.3969/j.issn.1673-4130.2015.08.035
- VernacularTitle:血清胃蛋白酶原与脂肪酸合酶联合检测在胃癌诊断中的意义
- Author:
Liyong HU
;
Shicui DAI
- Publication Type:Journal Article
- Keywords:
pepsinogen;
fatty acid synthase;
gastric cancer
- From:
International Journal of Laboratory Medicine
2015;(8):1092-1093
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical value of combination detection of serum pepsinogen (PG ) and fatty acid synthase (FAS) in the diagnosis of gastric cancer .Methods A total of 74 patients with gastric cancer were enrolled as gastric cancer group , 45 patients with benign gastric lesion were enrolled as benign gastric lesion group ,and 78 healthy individuals were enrolled as con‐trol group .Serum levels of PG and FAS were detected by using immunoturbidimetry and enzyme‐linked immunosorbent assay ,and comparatively analyzed between each group .Results Compared with control group ,serum level of PG Ⅰ and PGⅠ /PGⅡ ratio of gastric cancer group were decreased(P<0 .05) ,but serum level of FAS was increased(P<0 .05) ,and the difference of serum level of PGⅡ was not significant(P>0 .05) .The area under the receiver operating characteristic curve of combined detection of PG and FSA in gastric cancer group was 0 .972 ,higher than single detection of PG and FSA .Diagnostic sensitivity and specificity of com‐bined detection of PG and FSA were 95 .50% and 92 .32% ,higher than single detection .Conclusion Combined detection of PG and FAS could increase the diagnostic rate of gastric cancer ,which might have important clinical significant for the early diagnosis of gastric cancer .
