Progress and obstacles of induced pluripotent stem cell on hematologic disease

VernacularTitle:诱导多能干细胞在血液系统疾病中应用的研究进展
Author: Ting YANG ; Jianda HU
Publication Type:Journal Article
Keywords: Induced pluripotent stem cell; Blood cells; Leukemia; Drug resistance; Monogenic inherited disease
From: Journal of Leukemia & Lymphoma 2013;22(6):347-350
CountryChina
Language:Chinese
Abstract: Induced pluripotent stem (iPS) cell based on recently developed stem cell reprogramming technique holds great hope for regenerative medicine,in vitro disease modeling and drug evaluation.Recent progress on clinical hematology includes in vitro generation of hematopoietic progenitors and mature blood cells from somatic cells,iPS cells derived from chronic myeloid leukemia cells for the better understanding of the resistance mechanisms of bcr-abl inhibitor imatinib,and moreover,correction the monogenic inherited disease using gene-targeted strategies.However,whether the iPS cells can fully replace human embryonic stem cells still needs further investigation.