Differences between right-sided and left-sided intestinal cancers
10.3760/cma.j.issn.1673-422X.2015.04.018
- VernacularTitle:左右半大肠癌的差异
- Author:
Jiao YANG
;
Jianfei FU
;
Xian ZHONG
;
Ying YUAN
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Disease attributes;
Neoplasm site
- From:
Journal of International Oncology
2015;(4):305-308
- CountryChina
- Language:Chinese
-
Abstract:
Decreasing trend has occurred in incidence of colorectal cancer in developed countries. A shift from left to right in location of colorectal cancer has been recognized,which may be associated with colonoscopy screening,aging population,diet structure modification,increased incidence of cancer and diabe-tes. Factors including sex,race and education may also play a role to some extent. Right-sided intestinal cancers have higher proportion of poor differentiation,terminal stage and mucinous component. Complications and second primary intestinal cancer are more common in right-sided intestinal cancers. Left-sided intestinal cancers tend to be well differentiated and at relatively early stage at diagnosis. With respect to molecular mecha-nism,right-sided cancers are associated with mismatch repair system,while left-sided cancers are related to p53 mutation. Based on the differences in clinicopathology and genetics,it′s implied that left-sided and right-sided intestinal cancers may belong to two different kind of disease. It′s suggested that attentions should be paid differently according to their respective characteristics in clinical practice and trials.
