Expression of estrogen receptor and progesterone receptor on PTEN-deficient endometrial carcinoma
10.13315/j.cnki.cjcep.2015.07.006
- VernacularTitle:PTEN缺失型子宫内膜癌中ER、PR的表达及意义
- Author:
Yanfang LIANG
;
Jianbo RUAN
;
Dongping KANG
;
Lingmei WANG
;
Can CHEN
;
Jincheng ZENG
- Publication Type:Journal Article
- Keywords:
uterine neoplasm;
endometrial carcinoma;
estrogen receptor;
progesterone receptor;
PTEN;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2015;(7):744-747
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate estrogen receptor ( ER ) , progesterone receptor ( PR ) expression in PTEN-deficient endometrial carcinoma and to analysis the relationship of PTEN, ER and PR protein expression with histological grade, pathological staging and muscle invasive. Methods Immunohistochemistry EnVision was used to detect the expression of PTEN, ER and PR protein in 100 ca-ses of endometrial carcinoma. Results The rate of PTEN-deficient endometrial carcinoma was 52. 0% (52/100). The expression rate of ER, PR protein on PTEN-deficient endometrial carcinoma was 15. 4% (8/52), 19. 2% (10/52), respectively. And the expression rate of ER, PR protein on PTEN over-expression endometrial carcinoma was 72. 7% (8/11), 63. 6% (7/11), respectively. The rate of PTEN, ER and PR expression types shown PTEN-ER-PR- was 42. 0% (42/100), which was higher than other types (P <0. 05). Different PTEN, ER and PR expression types were well correlated with histological grade and pathological staging (P<0. 05), but not with muscle invasive. Conclusion Combined detection of PTEN, ER and PR may have an important reference value for prog-nosis and treatment of endometrial carcinoma.
