Research progress of ovarian cancer apoptosis related factor-Survivin and Smac

VernacularTitle:凋亡相关因子 Survivin 和 Smac 在卵巢癌中的研究进展
Author: Dan MA ; Ling MA
Publication Type:Journal Article
Keywords: Ovarian neoplasms; Cell apoptosis; Survivin; Smac
From: Journal of International Oncology 2015;(4):313-315
CountryChina
Language:Chinese
Abstract: Survivin is the strongest member of the inhibitor of apoptosis protein(IAP)family. Smac is the second mitochondria-derived activator of cysteine proteases,which can promote apoptosis by combining with IAP. Abnormal expression of them is closely related with occurrence,development,treatment tolerance and prognosis of ovarian cancer. It is prompted that Survivin and Smac are expected to play important roles in the early diagnosis and targeted therapy of ovarian cancer.