Expression and clinical significance of MGMT,Ki-67 and P53 in human gliomas
10.3760/cma.j.issn.1673-422X.2015.03.003
- VernacularTitle:MGMT和Ki-67及P53蛋白在脑胶质瘤中表达及意义
- Author:
Jun LAI
;
Lin LUO
- Publication Type:Journal Article
- Keywords:
Glioma;
O6-methylguanine DNA methyltransferase;
Cell proliferation-related nuclear pro-tein Ki-67;
Tumor suppressor protein p53
- From:
Journal of International Oncology
2015;(3):169-171
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of DNA repair enzyme O6-methylguanine DNA methyl-transferase(MGMT),cell proliferation-related nuclear protein(Ki-67)and P53 protein in gliomas,and inves-tigate the relationship and clinical significance among them and gloma grade. Methods 61 cases of brain glio-ma specimes and 16 cases of internal decompression of brain trauma were used to detect the expression of MGMT,Ki-67 and P53 by using immunohistochemical SP method. Results MGMT protein expression (19. 67%∶0,χ2 =3. 729,P=0. 062),Ki-67 protein expression(39. 34% ∶0,χ2 =5. 722,P=0. 016)and P53 protein expression(27. 87% ∶0,χ2 =9. 146,P=0. 002)showed significant differences in gliomas com-pared to normal brain tissues,the expression of Ki-67 was significantly higher in high-grade gliomas(Ⅲ-Ⅳ) than that in low-grade gliomas(Ⅰ-Ⅱ)(14 ∶10,χ2 =11. 718,P =0. 001). No significant difference was found between the MGMT and P53. Conclusion MGMT protein can be used as a biomarker in gliomas detec-tion;Ki-67 has a positive correlation with tumor grade,and can be used as a reference indicator of pathological grade;P53 protein expression may be used as a potential target for the treatment of gliomas.
