Ubiquitin and its role in the tumor
10.3760/cma.j.issn.1673-422X.2015.03.007
- VernacularTitle:泛素化及其在肿瘤中的作用
- Author:
Xiaojia GAO
;
Hui YANG
;
Lin WU
;
Fuxiang ZHOU
;
Yunfeng ZHOU
- Publication Type:Journal Article
- Keywords:
Ubiquitination;
Neoplasms;
Radiation tolerance;
Ubiquitin-conjugating enzyme E2D3;
Human telomerase reverse transcriptase
- From:
Journal of International Oncology
2015;(3):188-191
- CountryChina
- Language:Chinese
-
Abstract:
Ubiquitin-proteasome pathway is one of the primary pathway in intracellular protein degrada-tion,therefore the ubiquitin conjugating enzyme D3(UbE2D3)which involved in the ubiquitin mineralization process can affect the biological effects accordingly to affect some protein and nucleic acid content and activity. The function that participate in modification and degradation of some cancer factors is vital in tumor cells,and followed by tumor biological behavior changing. Researches show that UbE2D3 correlates with human telomer-ase reverse transcriptase( hTERT),radiation sensitivity,aggressive,etc in breast cancer.
