Mechanisms of helicobacter pylori on the occurrence of gastric cancer
10.3760/cma.j.issn.1673-422X.2015.03.015
- VernacularTitle:幽门螺杆菌致胃癌发生的作用机制
- Author:
Lai WU
;
Xiuyun HOU
- Publication Type:Journal Article
- Keywords:
Stem cells;
Helicobacter pylori;
Tumor microenvironment
- From:
Journal of International Oncology
2015;(3):218-220
- CountryChina
- Language:Chinese
-
Abstract:
Helicobacter pylori is one of causes of gastric cancer. It can cause mucosal inflammation cytokines aggregation,gastric mucosal damage;and through a variety of ways to activate epithelial cells multiple oncogenic pathways,including phosphatidylinositol 3 kinase( PI3K)pathway,Wnt-β-catenin and epoxidized synthase-2(COX-2)-prostaglandin E2 antibody(PGE2)pathway,so as to change the gastric stem cell micro-environment and disrupt the gastric stem cell differentiation and proliferation,making the normal gastric stem cells evolved into cancer stem cells.
