Akt inhibitors in the treatment of colorectal cancer
10.3760/cma.j.issn.1673-422X.2015.03.017
- VernacularTitle:Akt抑制剂及其在结直肠癌治疗中的研究现状
- Author:
Cunqi DIAO
;
Jingwang BI
;
Baocheng WANG
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Targeted therapy;
PI3K-Akt-mTOR signal pathway
- From:
Journal of International Oncology
2015;(3):224-227
- CountryChina
- Language:Chinese
-
Abstract:
Protein kinase B( Akt)is an intermediate signal molecule in PI3K-Akt-mTOR signaling pathway which plays an important role in development and incidence of colorectal cancer when activated by phosphorylation. As target of drugs,Akt has become a focus in the treatment of colorectal cancer. Clinical trials research proves that many kinds of Akt inhibitors have good antitumor activity. In recent years,the Akt inhibi-tors are more and more be taken seriously in colorectal cancer treatment.
