Analysis of the lymphocyte subsets in cerebrospinal fluid in patients with HIV infection
10.3969/j.issn.1673-4130.2015.08.017
- VernacularTitle:H IV 感染者脑脊液淋巴细胞亚群分析
- Author:
Xi QIAO
;
Jinlan SHEN
;
Ping ZENG
;
Tong LIU
;
Yanyan WANG
- Publication Type:Journal Article
- Keywords:
human immunodeficiency virus;
lymphocyte subsets;
flow cytometry;
cerebrospinal fluid
- From:
International Journal of Laboratory Medicine
2015;(8):1052-1054
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the lymphcyte subsets distribution in cerebrospinal fluid in patients with HIV infection ,and to investigate the clinical significance of the lymphocyte subsets in cerebrospinal fluid in HIV central nervous system complication . Methods 34 patients with HIV infection ,including 20 patients without nervous system symptoms (simple HIV group) and 14 pa‐tients with nervous system symptoms (neurological HIV group) ,and 15 cases of healthy people (control group) were selected . Flow cytometry was used to detect lymphocyte subsets ,and immunoturbidimetry was used to detect the level of IgG in cerebrospinal fluid .Results The percentage of CD8+ T cells was higher and percentage of CD4+ T cells was lower in the simple HIV group and neurological HIV group than those in the healthy control ,with statistically significant differences (P<0 .01) .The level of IgG in pa‐tients with HIV infection was higher than that in the healthy control group (P<0 .01) .While no significant difference were found in the percentage of B cells and NK cells among the there group (P>0 .05) .There were also no significant differece between the sim‐ple HIV group and neurological HIV group in the ratio of each lymphcyte subset in cerebrospinal fluid (P>0 .05) .Conclusion The immune disorder in cerebrospinal fluid in patients with HIV infection may appear in the early time before the nervous system com‐plication .The changing trends of lymphocyte subsets are consistent with the peripheral blood ,which demonstrate that the T lym‐phocyte subsets may be correlated with the nervous system symptoms of HIV .
