The value of serum retinol binding protein determination for the diagnosis of early renal damage in patients with type 2 diabetes mellitus
10.3969/j.issn.1673-4130.2015.08.019
- VernacularTitle:血清视黄醇结合蛋白检测对2型糖尿病患者早期肾功能损伤诊断的价值
- Author:
Guangrong LI
;
Jinbo LIU
;
Lan MING
- Publication Type:Journal Article
- Keywords:
receiver operating characteristic curve;
retinol binding protein;
diabetic nephropathy
- From:
International Journal of Laboratory Medicine
2015;(8):1057-1058
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic value of serum retinol binding protein (RBP) on the early stage of type 2 diabet‐ic nephropathy by receiver operating characteristic(ROC)curve .Methods According to urinary albumin(mAlb)/urinary creatinine (UCr) ratio ,155 patients with type 2 diabetes were divided into simple diabetic mellitus group ,early stage of diabetic nephropathy group ,and clinical stage of diabetic nephropathy group ,while healthy people were recruited randomly during the same period as con‐trol group .RBP test were performed by using immunoturbidimetry .The diagnostic value of RBP on in the early stage of type 2 dia‐betic nephropathy were evaluated by analyzing the ROC curve .Results The concentration of serum RBP in the early stage of dia‐betic nephropathy was significantly higher than that in the group of simple diabetic mellitus and control group (P<0 .05) ,the area under the ROC curve of RBP in serum was 0 .770 ,and the cutoff value was 40 .95 mmol/L ,while the sensitivity and the specificity were 81 .0% and 95 .2% .Conclusion RBP was a good marker in detecting early renal damage .
