The clinical significance of combined detection of combined detection of serum sTWEAK and cystatin C in early diabetic nephropathy
10.3969/j.issn.1673-4130.2015.08.030
- VernacularTitle:血清sTWEAK 和胱抑素C联合检测早期糖尿病肾病的临床意义
- Author:
Bei CHAO
;
Weifeng SHI
;
Zhijian ZHANG
- Publication Type:Journal Article
- Keywords:
diabetic nephropathy;
cystatin C;
sTWEAK;
glycosylated hemoglobin
- From:
International Journal of Laboratory Medicine
2015;(8):1082-1083
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of combined detection of serum sTWEAK and cystatin C in early di‐abetic nephropathy (DN) .Methods 35 patients with DN(DN group) ,56 patients with diabetes mellitus (DM ,DM group) and 40 healthy cases conducted physical examination (healthy control group) were selected and serum levels of sTWEAK and cystatin C were detected .And levels of glycosylated hemoglobin(HbA1c) and qualitative urine protein test were conducted in DM group .Re‐sults The serum sTWEAK level in DN group was lower than that in DM group ,and the serum cystatin C level was higher than that in DM group(P<0 .05) .The serum levels of sTWEAK in DM group and DM patients with negative qualitative urine protein were lower than that in healthy control group ,while the serum cystatin C levels were higher than that of control group (P<0 .05) . Compared with DM patients with HbA1C< 10% ,the serum cystatin C level was higher and serum sTWEAK level was lower of those with HbA1c>10% (P<0 .05) .Conclusion The combined detection of serum sTWEAK and cystatin C could be a sensitive index for early diagnosis of DN ,with important significance in the occurrence and development of DN .
