Effects of Rhamnocitrin in Oxytropis Falcata on Nonspecial Immune Function of ;Immunosuppressive Mice
10.3969/j.issn.1005-5304.2015.05.016
- VernacularTitle:藏药镰形棘豆鼠李柠檬素对免疫抑制小鼠非特异性免疫功能的影响
- Author:
Min GUO
;
Li ZHANG
;
Hua JIANG
- Publication Type:Journal Article
- Keywords:
Oxytropis Falcata;
rhamnocitrin;
immunosuppression;
nonspecific immunity;
mice
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2015;(5):57-59
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study action mechanism of rhamnocitrin in Oxytropis Falcata on enhance the immune function. Methods Kunming mice were randomly divided into blank control group, model group, positive control group, traditional Chinese medicine high, medium, and low dose groups. All treatment groups received gavage with relevant medicine for 10 days. From the 8th day, blank control group received intraperitoneal injection with normal saline, while other groups received intraperitoneal injection with cyclophosphamide for 3 days. Through macrophages carbon clearance test, macrophage phagocytosis of chicken erythrocytes test, and immunosuppressive mice organ index detection, effects of rhamnocitrin in Oxytropis Falcata on nonspecific immune function of immunosuppressive mice were observed. Results Compared with model group and blank control group, traditional Chinese medicine high, medium, and low dose groups could improve the phagocytic activity of immunosuppressive mice, clearance index, and phagocytic coefficient (P<0.05), and increase the organ index of the thymus and spleen. Compared with the positive control group, the efficacy of traditional Chinese medicine high, medium, and low dose groups was low. Conclusion Rhamnocitrin in Oxytropis Falcata can enhance the immune function, improve the formation of spleen cells of mice serum hemolysin of chicken red blood cell immune.