Influence of L-type Helicobacter pylori infection on invasion and metastasis of gastric cancer

VernacularTitle:幽门螺杆菌L 型感染对胃癌侵袭和转移能力的影响
Author: Yongjian LUO ; Jiaming YAN ; Yi XIAN
Publication Type:Journal Article
Keywords: L-type Helicobacter pylori; gastric cancer; invasion; metastasis
From: International Journal of Laboratory Medicine 2015;(8):1113-1114
CountryChina
Language:Chinese
Abstract: Objective To investigate the influence of L‐type Helicobacter pylori(Hp‐L) infection on invasion and metastasis of gastric carcinoma .Methods Carcinoma tissues and normal tissues were collected from 80 patients with gastric cancer ,and detected for Hp‐L ,matrix metalloproteinases‐9(MMP‐9) and vascular endothelial growth factor(VEGF) by using Gram staining ,immuno‐histochemistry staining and transmission electron microscope .Results Positive rate of Hp‐L in carcinoma tissues was 67 .50% , higher than the 23 .75% of normal tissues(P<0 .05) .Positive rates of MMP‐9 and VEGF of carcinoma tissues were also higher than normal tissues(P<0 .05) .Positive rates of VEGF and MMP‐9 of carcinoma tissues positive with Hp‐L were higher than carci‐noma tissues negative with Hp‐L(P<0 .05) .The positive rate of Hp‐L in carcinoma tissues was correlated with local and distant lymph node metastasis ,and invasion depth ,but not correlated with the size of tumor .Conclusion Hp‐L infection might be correla‐ted with carcinogenesis of gastric cancer ,and could also influence metastasis and invasion of gastric cancer .