Expression and significance of VEGF,MIF in colorectal cancer
10.3969/j.issn.1671-8348.2015.11.012
- VernacularTitle:大肠癌组织中VEGF、MIF的表达及临床意义
- Author:
Miaofeng WANG
;
Maoming XIONG
;
Huoyou LI
;
Tengyun LONG
- Publication Type:Journal Article
- Keywords:
colorectal neoplasms;
vascular endothelial grow th factors;
macrophage migration-inhibitory factors;
immunohis-tochemistry
- From:
Chongqing Medicine
2015;(11):1478-1480
- CountryChina
- Language:Chinese
-
Abstract:
Objective Todetecttheexpressionofvascularendothelialgrowthfactor(VEGF)andmigrationinhibitoryfactor (MIF) in colorectal cancer .Methods The immunohistochemical staining (SP method) was used to measure the expression of VEGF and MIF in 80 samples of colorectal cancer and 80 samples of normal colorectal tissues at 5 cm apart from the tumor edge . The relationship between VEGF and MIF with the clinical pathologic characteristics of colorectal cancer was anlyzed .Results The positive rates of VEGF and MIF in the colorectal cancer tissues were 77 .50% and 82 .50% respectively ,but which in the normal colorectal tissues were 22 .50% and 27 .50% respectively ,the positive rate of VEGF and MIF expression in the colorectal cancer tis‐sues were higher than that in the normal colorectal tissue with statistical difference (P<0 .05) .The expression of VEGF and MIF had correlation with the tumor infiltration depth ,lymph node metastasis ,and clinical stage ,but no correlation with gender ,age and histodifferentiation .Conclusion VEGF and MIF are highly expressed in the colorectal cancer tissues .
