Changes of plasma tumor necrosis factor-α and monocyte chemoattractant protein-1 content in patients with coronary heart disease and their clinical significance
10.3969/j.issn.1008-0074.2015.02.11
- VernacularTitle:冠心病患者血浆肿瘤坏死因子-α和单核细胞趋化蛋白-1含量的变化及其意义
- Author:
Lijun LIU
;
Shuanli XIN
;
Renjie ZHANG
;
Shuli ZHANG
;
Yanli LIU
;
Liping DUAN
;
Jixiang LIU
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Angina pectoris;
Tumor necrosis factor-alpha;
Monocyte chemotactic protein-1
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2015;24(2):153-155
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the role of tumor necrosis factor‐α(TNF‐α) and monocyte chemoattractant protein‐1 (MCP‐1) in pathogenesis of angina pectoris of coronary heart disease (CHD) .Methods :A total of 60 CHD pa‐tients diagnosed by coronary angiography (CAG) were selected and divided into stable angina pectoris (SAP) group (n=28) and unstable angina pectoris (UAP) group (n=32) ,and another 30 cases with normal CAG results were re‐garded as normal control group .Immune turbidity method and enzyme linked immunosorbent assay were used to measure plasma levels of TNF‐αand MCP‐1 respectively .Results:Compared with normal control group ,there were significant rise in plasma levels of TNF‐α[ (15.18 ± 4.12) ng/L vs .(18.56 ± 4.22) ng/L vs .(21.79 ± 4.43) ng/L] and MCP‐1 [(10.23 ± 3.21) pg/L vs .(14.67 ± 3.42) pg/L vs .(17.86 ± 3.51) pg/L] in SAP group and UAP group , P<0.01 all ,and those of UAP group were significantly higher than those of SAP group , P<0.01 both .Conclusion:Plasma tumor necrosis factor‐αand monocyte chemoattractant protein‐1 levels significantly rise ,it possesses impor‐tant clinical significance for predicting existence and development of coronary heart disease .
