Advances in Study on Intestinal Apical Sodium-dependent Bile Acid Transporter and Related Diseases
10.3969/j.issn.1008-7125.2015.04.008
- VernacularTitle:肠道顶端钠离子/胆汁酸转运体及其相关疾病研究进展
- Author:
Hanyu WANG
;
Shengliang CHEN
- Publication Type:Journal Article
- Keywords:
Cholic Acids;
Apical Sodium-Dependent Bile Acid Transporter;
Inflammation;
Neoplasms;
Microbiota;
Gut-Liver Axis
- From:
Chinese Journal of Gastroenterology
2015;(4):244-247
- CountryChina
- Language:Chinese
-
Abstract:
Bile acids play critical roles in the solubilization and absorption of lipids. The ileal apical sodium-dependent bile acid transporter( ASBT)located at the enterocyte brush border is responsible for the reuptake of bile acids and the maintenance of bile acid homeostasis. Recently,great success has been made in understanding the relationship between ASBT and intestinal inflammation,tumorigenesis,secretion,motility,sensation,gut microbiota,and gut-liver axis in addition to its expression regulation,which implicates ASBT as a contributor of some gastrointestinal diseases and a promising new therapeutic target for these diseases. In this review article,the advances in study on above-mentioned issues were summarized.
