Comparison of the Bama minipig and Juema minipig models of high altitude multi-organ dysfunction syndrome
10.3969/j.issn.1671.7856.2015.004.007
- VernacularTitle:蕨麻小型猪与巴马小型猪高原多脏器功能障碍综合征模型的比较研究
- Author:
Tingxian NIU
;
Xiaoyu GUO
;
Jian SHEN
;
Hongyi WANG
;
Lu LU
;
Pan XIAO
;
Xiaoming FENG
- Publication Type:Journal Article
- Keywords:
High altitude multi-organ dysfunction syndrome;
Juema minipig;
Bama minipig;
Animal model
- From:
Chinese Journal of Comparative Medicine
2015;(4):33-37
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the Bama minipig and Juema minipig models of high altitude multi-organ dysfunction syndrome.Methods Six plateau-origin Juema minipigs and plain-origin Bama minpigs in each group received intravenous infusion of 0.35 mg/kg lipopolysaccharide ( LPS) , respectively.Blood samples were taken at 0 h, 3 h, 6 h, 12 h, 24 h, 48 h and 72 h after LPS infusion.Routine blood test was performed, blood CK, AST, ALT, TBIL, CRE were assayed, and histopathological examination of the lung tissues was performed at 24 h, 48 h after LPS infusion.Results The mortality of Bama minipigs was 33.3%, higher than that of 16.7%of Juema minipigs.The trend of physiological and biochemical changes was similar, but was milder in the Juema minipigs than in Bama minipigs.The lung injuries of the Bama minipigs at 24 h and 48 h were more severe than those in the Juema minipigs.Conclusions Both Bama and Juema minipig models of high altitude multi-organ dysfunction syndrome can be successfully established.Juema minipig models can be more closely and safely established, due to its own plateau biological properties, and avoid the influence by extrinsic injurious effects of plateau environment.
