Study on Enhancing Efifcacy and Reducing Toxicity of Total Flavonoids, Total Polysaccharides inTaxus mairei Compatibility with Taxol
10.11842/wst.2015.03.023
- VernacularTitle:南方红豆杉总黄酮、总多糖与紫杉醇配伍增效减毒作用研究
- Author:
Wei CAI
;
Miaofen XIA
;
Yaokang XIONG
- Publication Type:Journal Article
- Keywords:
Taxus mairei;
taxol;
total flavonoids;
total polysaccharides;
enhancing efficacy and reducing toxicity
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2015;17(3):556-562
- CountryChina
- Language:Chinese
-
Abstract:
This article was aimed to study enhancing efficacy and reducing toxicity on anti-tumor from total flavonoids and total polysaccharides in Taxus mairei compatibility with taxol. MTT assay was performed to analyze the cell proliferation and apoptosis of 4T1, A549, MCF-7 tumor cells after treatment of total flavonoids and total polysaccharides in T. mairei combined with taxol at different concentrations. Isobolograms was used to investigate the behavior of combination therapy. Therapy experiments were conducted on ICR mice bearing S180 sarcoma. The tumor weight was measured to calculate inhibition rate according to uniform design. Blood cells indicators were detected by blood cell analyzer. The results showed that total polysaccharides and total flavonoids can enhance the inhibition effect on 4T1, A549 cells by taxol. Total polysaccharides can enhance the inhibition effect of taxol to MCF-7 in vitro, and S180 sarcoma-bearing mice in vivo. It reduced the toxic effects of anti-tumor effect of taxol in vivo. It was concluded that taxol can achieve the effect of enhancing efficacy and reducing toxicity through combining with total flavonoids and total polysaccharides in T. mairei.
