Chemical Constituents fromVitex negundoL.var. cannabifolia

VernacularTitle:牡荆叶化学成分研究
Author: Manman LI ; Zheng HUANG ; Huixia HUO ; Jing ZHANG ; Jiao ZHENG ; Qian ZHANG ; Yunfang ZHAO ; Jun LI ; Pengfei TU
Publication Type:Journal Article
Keywords: Verbenaceae; Vitex; Vitex negundovar. cannabifolia; flavonoid; caffeoylquinic acid ester
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2015;17(3):578-582
CountryChina
Language:Chinese
Abstract: This study was aimed to investigate the chemical constituents from the leaves of Vitex negundovar. cannabifolia. Column chromatography including silica gel, Sephadex LH-20, ODS, and semi-preparative HPLC were used to separate and purify the chemical constituents, and the structures were elucidated on the basis of physicochemical properties, MS and NMR spectroscopic data. As a result, 11 compounds were isolated from the ethyl acetate extract of V. negundo var. cannabifolia, and identified as apigenin (1), penduletin (2), chrysosplenol-D (3), quercetin (4), 1,4-dihydroxy-3R,5R-dicaffeoyloxy cyclohexane carboxylic acid (5), maeranthoin F (6), capsidiol (7), caryolandiol (8), β-sitosterol (9), p-hydroxybenzonic acid (10), and β-daucosterin (11). It was concluded that compounds 5 8were firstly isolated from the plants of Vitex genus, and compounds 1 and 4 were isolated from V. negundovar. cannabifolia for the first time.