Research progress on type Ⅱ innate lymphoid cells in respiratory mucosal immunity and lung diseases
10.3969/j.issn.1000-484X.2015.04.001
- VernacularTitle:呼吸道Ⅱ型固有淋巴细胞与肺脏疾病研究进展
- Author:
Chao HUANG
;
Zhigang TIAN
- Publication Type:Journal Article
- Keywords:
ILC2s;
Development;
Regulation;
Lung;
Infection;
Asthma
- From:
Chinese Journal of Immunology
2015;(4):433-439
- CountryChina
- Language:Chinese
-
Abstract:
Type Ⅱ innate lymphoid cells is an emerging family of innate lymphocytes mainly distributed in mucosal tissues such as the lungs,intestines,skin,etc.These cells are capable of producing Th2-type cytokines including IL-5 and IL-13 in response to IL-25 and IL-33.ILC2s has attracted much attention for its important roles in anti-infection immunity and allergic diseases in respiratory tract.Studies have shown that ILC2s represented a crucial source of Th2-type cytokines and could regulate the adaptive immune response in allergic airway diseases.Meanwhile,ILC2s was able to fulfill vital functions in parasite clearance, anti-virus infection and subsequent tissue repair.Therefore,research in ILC2s phenotype,development and function has great practical significance.This paper reviews the definition, classification, developmental regulation of ILC2s with a particular focus on its role in respiratory mucosal homeostasis and lung-related diseases.
