The expressions of hypoxia-inducible factor 1αand carbonic anhydrase IX in gestational trophoblastic disease
10.7652/jdyxb201503010
- VernacularTitle:缺氧相关蛋白 HIF-1α和 CAIX 在妊娠滋养细胞疾病中的表达
- Author:
Weihua ZHOU
;
Ruifang AN
- Publication Type:Journal Article
- Keywords:
gestational trophoblastic disease;
hypoxia;
hypoxia-inducible factor 1α(HIF-1α);
carbonic anhy-drase IX (CAIX);
immunohistochemistry
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2015;(3):337-340
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of hypoxia-inducible factor 1α(HIF-1α)and carbonic anhydrase IX (CAIX)in oncogenesis and development of gestational trophoblastic disease (GTD).Methods The expressions of HIF-αand CAIX were determined immunohistochemically by specific antibodies on formalin-fixed paraffin sections of normal pregnancy villi (32 cases),hydatidiform moles (33 cases),and invasive hydatidiform moles (26 cases). Results The positive rate of HIF-1α in normal pregnancy villi (NP),hydatidiform moles (HM)and invasive hydatidiform moles (IM) was 28.1% (9/32 ), 45.5% (1 5/33 ) and 73.1% (1 9/26 ), respectively. It was significantly higher in IM than in HM and NP(P <0.05),and there was no statistical difference between the latter two groups (P >0.05).The positive rate of CAIX in NP,HM and IM was 31.2 (10/32),3.0(1/33)and 57.7%(1 5/26),respectively.It was significantly higher in IM than in HM and NP (P < 0.05 ),and CAIX was almost negatively expressed in HM group,which differed significantly from that in NP group (P <0.05 ).There was no correlation between HIF-1αand CAIX expressions in IM (P >0.05).Conclusion The expressions of HIF-1αand CAIX were both higher in gestational trophoblastic neoplasia than in normal pregnancy and hydatidiform moles, which indicates that HIF-1αand CAIX may play a role in oncogenesis and development of malignant transformation of trophoblastic cells.
