Expressions of Twist and VEGF in epithelial ovarian cancer

VernacularTitle:Twist 和 VEGF 在上皮性卵巢癌中的表达
Author: Lina YANG ; Juan WU ; Jing ZHAO ; Bin DAI ; Hong YANG
Publication Type:Journal Article
Keywords: ovarian cancer; Twist; vascular endothelial growth factor (VEGF); immunohistochemistry
From:Journal of Xi'an Jiaotong University(Medical Sciences) 2015;(3):341-344
CountryChina
Language:Chinese
Abstract: Objective To investigate the role of Twist and vascular endothelial growth factor (VEGF)in the development of epithelial ovarian cancer and their relationship with clinical pathological features.Methods The expressions of Twist and VEGF were detected by immunohistochemical staining (SP)method in 80 cases of epithelial ovarian cancer and 10 paired cases of normal ovarian tissue.Results In the 80 cases of ovarian cancer tissues,the positive expression rate of Twist and VEGF in epithelial ovarian cancer was 85% and 86.25%,respectively,which were remarkably higher than those in normal ovarian tissues (P <0.01).The expressions of Twist and VEGF were closely associated with clinical stages,pathological grades and lymph node metastasis,but not correlated with age or pathological patterns (P >0.05).There was a significant correlation between the expressions of Twist and VEGF in epithelial ovarian cancer (r =0.646,P <0.01).Conclusion The high expressions of Twist and VEGF may play a potential role in the occurrence,development and invasion process of epithelial ovarian cancer.