Relationship between tumor necrosis factor-αgene-308 promoter polymorphism and susceptibility to development of bronchial asthma in Uighur and Kazakh population in Xinjiang
10.7652/jdyxb201503019
- VernacularTitle:TNF-α基因-308位点多态性与新疆维吾尔族、哈萨克族人群中支气管哮喘的关系
- Author:
Jia ZHU
;
Zhongkai LI
;
Min LING
- Publication Type:Journal Article
- Keywords:
bronchial asthma;
polymorphism;
tumor necrosis factor-α(TNF-α)gene;
uighur;
kazakh;
Xinjiang
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2015;(3):383-386
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the polymorphism of the tumor necrosis factor-αgene-308 promoter and bronchial asthma (BA)in Uighur and Kazakh population in Xinjiang.Methods PCR product sequencing method was used to detect the polymorphism distribution of TNF-αgene in 60 BA patients and 60 controls among Xinjiang Uighur and Kazakh population.Then we analyzed the association between different TNF-αgenotypes and BA in Uighur and Kazakh population.Results The distribution of GG,GA and AA genotype was significantly different between the two groups.Statistical analysis showed that BA group had a significantly higher TNF-αA allele frequency than that of the control one (P <0.05).After adjustment for sex and age,we found the A allele was a risk factor for BA pathogenesis (P <0.05).Conclusion The polymorphism of TNF-α gene-308 may be associated with the susceptibility to BA in Xinjiang Uighur and Kazakh population,so TNF-α gene-308 may be considered as a genetic marker for early identification of individuals at high risk for BA,which may play an important role in preventing the development of BA in clinical practice.
