The role of unbalanced expression of endothelin receptor (ETA/ETB)in basilar artery vasospasm after subarachnoid hemorrhage in rats
10.7652/jdyxb201503021
- VernacularTitle:蛛网膜下腔出血后内皮素受体（ETA/ETB）不平衡表达在大鼠基底动脉痉挛中的作用
- Author:
Leitao SUN
;
Jinning SONG
;
Hongpeng DU
;
Xiaohong WANG
;
Meng LI
;
Zefu LI
- Publication Type:Journal Article
- Keywords:
endothelin receptor;
cerebral vasospasm;
subarachnoid hemorrhage;
basilar artery
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2015;(3):391-394
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mechanism of unbalanced expressions of endothelin receptors (ETA/ETB )in cerebral vasospasm (CVS)after subarachnoid hemorrhage (SAH).Methods The rat CVS models were established by injecting autologous blood into the cisterna magna the second time.Basilar artery morphology was observed under light microscope and immunofluorescence staining was conducted to dynamically detect ETA/ETB receptor expression.Results The cross-sectional area of the basilar artery in the SAH model group decreased at 2 d to 3 d,and then gradually returned to normal.ETA receptor expression in endothelial cells of the basilar artery increased at 2 d after SAH,peaked at 3 d and remained increased till 14 d.ETB receptor expression increased significantly in endothelial cells at 3 d,peaked at 7 d and remained the same level till 14 d.Conclusion The results suggest that ETA/ETB receptors play an important role in cerebral vasospasm after SAH.The specific expression differences of ETB receptor subtypes in the brain vascular layers need further study.
