Relationship between ACE gene (I/D) polymorphism and familial essential hypertension
10.3969/j.issn.1008-0074.2015.02.03
- VernacularTitle:ACE 基因（I/D）多态性与家族性原发性高血压的关系
- Author:
Tan XUE
;
Jing SHI
;
Xiuyan WANG
;
Juan LI
;
Xiaoyu LIANG
- Publication Type:Journal Article
- Keywords:
Angiotensin converting enzyme;
Polymorphism,single nucleotide;
Hypertension
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2015;24(2):127-130
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between angiotensin converting enzyme (ACE) gene insertion/dele‐tion (I/D) polymorphism and familial essential hypertension (EH) .Methods :Fluorescent in situ hybridization stai‐ning DNA sequencing test was used to detect ACE gene I/D genotype frequency and allele frequency in 46 familial EH patients (familial EH group) ,64 EH patients without family history (non‐familial EH group) and 43 healthy people (healthy control group) .Results:In healthy control group ,non -familial EH group ,familial EH group ACE gene DD genotype frequency was 11.6% ,32.3% and 37.0% ;distribution frequency of D allele was 33.7% , 52.3% and 57.6% respectively .Compared with healthy control group ,there were significant rise in ACE gene DD genotype and D allele frequency in familial EH group and non -familial EH group (P<0.05 or <0.01) ,but there were no significant difference between familial EH group and non‐familial EH group (P>0.05) .Conclusion:ACE gene DD genotype and D allele may be genetic predisposing genes of patients with essential hypertension ,and there is no significant difference in genetic constituent ratio between familial EH patients and non‐familial EH patients .
