Association of Neuropeptide S Receptor 1 Gene Polymorphisms with Inflammatory Bowel Disease
10.3969/j.issn.1008-7125.2015.04.003
- VernacularTitle:神经肽S受体1基因多态性与炎症性肠病相关性的研究
- Author:
Shi LIU
;
Xiaobing WANG
;
Feng ZHOU
;
Ting WU
;
Rui ZHOU
;
Jing LIU
;
Bing XIA
- Publication Type:Journal Article
- Keywords:
Inflammatory Bowel Disease;
Neuropeptide S Receptor 1;
Polymorphism,Single Nucleotide;
Genetic Predisposition to Disease;
China
- From:
Chinese Journal of Gastroenterology
2015;(4):205-209
- CountryChina
- Language:Chinese
-
Abstract:
Background:Studies showed that neuropeptide S receptor 1(NPSR1)gene polymorphisms were associated with the susceptibility of inflammatory bowel disease( IBD)in Europe’s populations,however,there is no study on the relevance in Chinese population. Aims:To investigate the association of NPSR1 gene polymorphisms with IBD in Chinese Han population. Methods:A total of 457 IBD patients[355 cases of ulcerative colitis(UC)and 102 cases of Crohn’s disease ( CD)]from Zhongnan Hospital of Wuhan University and 500 healthy controls were recruited. Genotyping of 2 single nucleotide polymorphisms(SNPs)of NPSR1,rs323922(C→G mutation)and rs740347(G→C mutation)was performed by using PCR and sequencing techniques. Results:Differences of the frequencies of genotypes and alleles for rs323922 and rs740347 between UC,CD patients and controls didn’t reach statistical significance(P >0. 05). Genotype-phenotype analysis showed that there were some impact of genotypes for rs323922 and rs740347 on clinical phenotypes of IBD:( i) For rs323922,mutant CG genotype was correlated with male CD patients(OR:0. 441,95% CI:0. 230-0. 844)and CD involving the colon(OR:0. 425,95% CI:0. 199-0. 911),and might be a protective factor.(ii)For rs740347,mutant CC genotype was correlated with early onset CD patients( <16 years old)(OR:15. 019,95% CI:2. 634-86. 470)and mutant C allele was correlated with CD involving the colon(OR:2. 142,95% CI:1. 709-4. 294),both were risk factors. Conclusions:Polymorphisms of NPSR1 rs323922 and rs740347 are not contributors of IBD susceptibility in Chinese Han population,but might be correlated with some clinical phenotypes of IBD.
