Study on blood selenium level and glutathione peroxidase activity in gestational diabetes mellitus
10.3969/j.issn.1671-8348.2015.10.017
- VernacularTitle:妊娠期糖尿病与血硒水平及谷胱甘肽过氧化酶活性的研究
- Author:
Fangliang PENG
;
Rong YIN
;
Xiao ZHOU
- Publication Type:Journal Article
- Keywords:
diabetes,gestational;
selenium;
glutathione peroxidase;
biomedical research
- From:
Chongqing Medicine
2015;(10):1345-1346
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between the blood selenium level and glutathione peroxidase(GSH-Px)with the occurrence of gestational diabetes mellitus(GDM).Methods Among 1 360 pregnant women in our hospital from January 2011 to December 2012,68 cases GDM were diagnosed as GDM (observation group)and other 113 non-GDM pregnant women were ran-domly selected from these 1360 pregnant women as the control group.The serum selenium level and GSH-Px activity were com-pared between the two groups.Results The selenium level and GSH-Px activity in the control group were higher than those in the observation group.The selenium level was (3.07±0.51)mmol/L in the control group and (2.06±0.41)mmol/L in the observa-tion group,respectively;the GSH-Px activity was (197.23±18.73)U in the control group and (151.35±19.67)U in the observa-tion group,the differences between the two groups were statistically significant (P <0.05).Conclusion The decrease of serum se-lenium level and GSH-Px activity may be one of the pathogenic causes of GDM.
