An association analysis on rs1412125 at HMGB1 with atrial fibrillation
10.3969/j.issn.1006-5725.2015.06.006
- VernacularTitle:HMGB1基因上SNP rs1412125与心房颤动的相关性
- Author:
Li LI
;
Zhen DU
;
Jun YANG
;
Jiawang DING
;
Jin SUN
;
Jiong ZHANG
;
Wanping CHEN
;
Song LI
;
Zhiyang LV
;
Yong CHEN
- Publication Type:Journal Article
- Keywords:
Atrial fibrillation;
HMGB1;
rs1412125;
Association analysis;
Interaction
- From:
The Journal of Practical Medicine
2015;(6):884-887
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of rs1412125 at high-mobility group box 1 (HMGB1) gene with atrial fibrillation (AF) in Chinese Han population. Methods 396 patients with AF and 726 control subjects were recruited to this study. A case-control association analysis was applied to assess the as-sociation between rs1412125 in HMGB1 and AF. Results There were no significant differences in rs1412125 and the frequency of genotype distribution between the study group and the control group (allelic association:object P value was 1.05E-06, adjust P value was 0.176; genotypic association: additive P value was 0.146, dominant P value was 0.162, and recessive P value was 0.998). The interactions analysis showed that rs1412125 allele C increased the risk of AF in male subjects with rheumatic heart disease (adjust P value was 2.07E-04, rectify OR = 8.20, and 95%CI: 2.70-25.0). Conclusions There is no independent genetic association between rs1412125 at HMGB1 and atrial fibrillation. However , the interactions between rs1412125 and both gender and rheumatic heart disease might increase the risk of atrial fibrillation.
