Inflammation-related signaling pathways of differently-methylated DNA from benign and malignant ;thyroid tumors in one patient
10.3969/j.issn.1006-5725.2015.06.012
- VernacularTitle:同一患者中甲状腺良性瘤与癌组织DNA甲基化差异基因的炎症相关信号通路分析
- Author:
Long GU
;
Liangliang CAI
;
Guoyan LIU
;
Runsheng RUAN
;
Chimeng TZENG
- Publication Type:Journal Article
- Keywords:
Thyroid neoplasms;
Papillary thyroid carcinoma;
Thyroid benign tumor;
DNA methylation;
Signaling pathway;
Inflammation
- From:
The Journal of Practical Medicine
2015;(6):901-904
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the possible differences in DNA methylation of benign and malignant thyroid tumors and its role in tumorgenesis and tumor progression. Methods Infinium human methylation 450 bead chip platform was utilized to screen the whole-genome of benign and malignant thyroid tumor tissues surgically removed from a patient for the determination of their DNA methylation levels. The genes with significant differences in methylation were analyzed for their functional pathways with bioinformatics. Results There were significant differences in DNA methylation between benign and malignant thyroid tumor. The inflammation-related pathways, such as T cell, Jak-STAT and cytokine-cytokine receptor signaling pathways involved in the biological process of tumorgenesis and tumor progression. Conclusions The differences in DNA methylation between benign and malignant reveal a close relationship between inflammation and tumorgenesis and tumor progression and provide a novel method for investigation of thyroid cancer development and target drug discovery.
