Expressions of CDX2 and β-catenin in acute lymphoblastic leukemia and their correlation
10.3969/j.issn.1006-5725.2015.06.016
- VernacularTitle:急性淋巴细胞白血病CDX2和β鄄catenin基因表达的相关性
- Author:
Wei WANG
;
Can MENG
;
Qinghua LI
;
Liang LIANG
;
Honghua HE
;
Guocai WU
;
Jia LIU
;
Zhigang YANG
- Publication Type:Journal Article
- Keywords:
Acute lymphoblastic leukemia;
CDX2;
β-catenin
- From:
The Journal of Practical Medicine
2015;(6):915-918
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of CDX2 and β-catenin in acute lymphoblastic leukemia (ALL) and their correlation. Methods Real-time PCR was used to determine the expressions of CDX2 and β-catenin mRNA in 43 de novo ALL and 30 non-malignant patients (used as control). Results The positivity rate of CDX2 mRNA expression in ALL group was 93%, but CDX2 mRNA expression couldn′t be detected in the control group (P<0.01). The mRNA expression of β-catenin could be detected in patients in both two groups, butβ-catenin mRNA expression in the ALL group was significantly higher than in the control group (P < 0.01). And mRNA expressions of CDX2 andβ-catenin were significantly correlated with WBC counts and LDH level (P<0.01). When the ALL patients acquired complete remission (CR), the mRNA expressions of CDX2 and β-catenin were significantly decreased compared with their newly diagnosed status , while disease-relapsed the mRNA expressions of CDX2 andβ-catenin were increased again. There was significantly positive correlation between CDX2 and β-catenin mRNA expressions (r = 0.835, P = 0.000). Conclusion Up-regulation of CDX2 and activation of Wnt/β-catenin pathway coexist in the ALL patients and the mRNA expressions of CDX2 and β-catenin are positively correlated.
