Ovarian protection with goserelin during adjuvant chemotherapy for pre-menopausal women with breast ;cancer

VernacularTitle:戈舍瑞林对绝经前乳腺癌患者辅助化疗期间卵巢功能的保护作用
Author: Guohua REN ; Meili MA ; Yuji AN ; Lijun SHENG
Publication Type:Journal Article
Keywords: Breast neoplasms; Goserelin; Ovarian function; Chemotherapy
From: The Journal of Practical Medicine 2015;(6):992-994
CountryChina
Language:Chinese
Abstract: Objective To observe the protective effect of goserelin on ovarian function of premenopausal patients with breast cancer during chemotherapy. Methods Forty patients with breast cancer under 40 received adjuvant chemotherapy were randomly divided intotest group(20 cases) and control group (20 cases). Compared the recovery rate and time of menstruation between two groups. Results All the 40 patients finished the treatment. Recovery ratio of normal ovarian function in test group and control group was 75% and 50% (P =0.013) respectively, and the median menstrual recovery time in two groups was 4.65 months and 6.65 months (P = 0.046) respectively. Statistically significant differences were found between two groups. Conclusion Goserelin can effectively protect ovarian function during chemotherapy , increase the ratio of normal ovarian function, shorten menstrual recovery time, and shows good tolerance.