Targeting Effect of Curcumin Gelatin Microspheres in Rats in vivo
10.3870/yydb.2015.04.006
- VernacularTitle:姜黄素明胶微球在大鼠体内靶向性研究
- Author:
Jungang DENG
;
Wei CHEN
;
Guihong HUANG
;
Jiang LI
;
Hang DENG
- Publication Type:Journal Article
- Keywords:
Curcumin;
Gelatin microsphere;
Targeting efficiency
- From:
Herald of Medicine
2015;(4):445-447
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the targeting effect of curcumin gelatin microsphere in rats in vivo. Methods Injections of curcumin gelatin microsphere and curcumin were injected via tail vein, respectively. HPLC was used to determine the content of curcumin in different organs. The pharmacokinetic parameters were calculated on the basis of compartment models by using DAS 2. 0 program. Targeting efficiency was used to evaluate tissue distribution of curcumin. Results Targeting efficiency of curcumin gelatin microsphere in heart, liver, spleen, lung and kidney was 0. 875, 0. 121, 1. 182, 5. 834 and 0. 896, respectively. Conclusion Curcumine gelatin microspheres can improve lung-targeting efficiency, and benefit for study on lung targeting therapeutic effect.
