Optimization of the Formula of Konjac Glucomannan-Paeonol Matrix Tablets
10.3870/yydb.2015.04.022
- VernacularTitle:魔芋胶-丹皮酚骨架片处方优化
- Author:
Jing JIE
;
Shufang NIE
;
Bo YANG
;
Xiaojing LAI
;
Donglin LIU
- Publication Type:Journal Article
- Keywords:
Konjac glucomannan-paeonol;
Matrix tablets;
Formula optimization;
Release rate,accumulative;
Orthogonal experiment
- From:
Herald of Medicine
2015;(4):502-505
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the formula of konjac glucomannan-paeonol matrix tablets. Methods The formula of paeonol matrix tablets was optimized by the orthogonal design with the accumulative release rate in vitro as index, with the viscosity of konjac glucomannan ( KGM) , the amount of KGM and lactose as influence factors. Results The optimized formula was as follows:the viscosity of konjac glucomannan was 20 000 mPa·s, KGM 30%, lactose 20% and the release in vitro fit into the Higuchi equation. Conclusion The formula of the paeonol matrix tablets is reasonable and the tablets have well release effect in vitro.
