Diagnostic value of HNF-1βin the diagnosis of ovarian clear cell carcinoma
10.13315/j.cnki.cjcep.2015.03.010
- VernacularTitle:卵巢透明细胞癌中HNF-1β的诊断价值
- Author:
Kemei XIONG
;
Wenbin HUANG
;
Jinsong WANG
;
Qing LI
;
Xue CHENG
- Publication Type:Journal Article
- Keywords:
ovarian neoplasm;
clear cell carcinoma;
HNF-1β;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2015;(3):282-285
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To study the expression of HNF-1β in different type ovarian carcinoma and to explore the diagnostic value of HNF-1β in the diagnosis of ovarian clear cell carcinoma. Methods Immunohistochemical EnVision method was used to detect the ex-pression of HNF-1βin 27 clear cell carcinomas, 35 high-grade serous carcinomas, 21 endometrioid adenocarcinoma, 10 mucious carci-nomas, 13 metastatic Krukenberg tumors, and 2 transitional carcinomas. Results All of ovarian clear cell carcinomas variably ex-pressed HNF-1β and the positive rate of HNF-1β in ovarian cleat cell carcinoma was 85. 2%. Of 21 ovarian serous carcinomas, the nuclear positive of HNF-1β was 4 and HNF-1βpositive rate was 2. 9%. There was 5 HNF-1βexpression in endometrioid adenocarci-noma and the positive rate of HNF-1β was 23. 8%. The positive rate of HNF-1β in mucious carcinoma and metastatic Krukenberg tumor was 60. 0% and 53. 8%, respectively. No HNF-1βexpression was seen in transtional cell carcinoma. The sensitivity and speci-ficity of HNF-1β in the diagnosis of ovarian clear cell carcinoma was 85. 2% and 76. 5%. Conclusions HNF-1β may be a higher sensitive marker for the diagnosis of ovarian clear cell carcinoma. The diffuse and strong positive of HNF-1βmay have higher specific for diagnosis of ovarian clear cell carcinoma.
