Analysis of clinicopathological characters for IgG4-related disease
10.13315/j.cnki.cjcep.2015.03.012
- VernacularTitle:IgG4相关性疾病临床病理学特征分析
- Author:
Weixiang ZHONG
;
Ke SUN
;
Xiaodong TENG
- Publication Type:Journal Article
- Keywords:
IgG4-related diseases;
IgG4;
IgG;
clinicopathological characters
- From:
Chinese Journal of Clinical and Experimental Pathology
2015;(3):289-292
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To study the clinicopathological features and immunohistochemical characteristics of IgG4-related disease. Meth-ods The microscopic characteristics and immunohistochemical staining (EnVision) of IgG, IgG4, CD138 and CD34 have been per-formed on 12 cases of IgG4-related disease. Results IgG4-related disease were characterized by diffuse fibrosis, accompanied with in-filtrating of dense lymphocytes and plasma cells surrounding neurovascular and occlusive phlebitis. Immunohistochemical staining re-sults showed the ratio of IgG4+/IgG+ cells were over 40%. Conclusions IgG4-related disease is absent of characteristic clinical and radiographic features and is easily misdiagnosed as tumor. Preoperative serum IgG4 detection could be used as the prior examina-tion for the suspected cases.
