Expression of EZH2 and p53 in breast cancer and their clinical significance
10.13315/j.cnki.cjcep.2015.03.008
- VernacularTitle:乳腺癌中EZH2和p53蛋白表达及其临床意义
- Author:
Xiaoxia WANG
;
Gang MENG
;
Li LI
;
Yuejun WANG
;
Miaomiao YANG
;
Biao HAN
;
Qing CHEN
;
Wen HUANG
- Publication Type:Journal Article
- Keywords:
breast neoplasm;
invasive ductal carcinoma;
invasive lobular carcinoma;
EZH2;
p53;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2015;(3):273-276
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the expression of EZH2 and p53 protein in breast cancer and to analyze their relationship with the clinical pathologic characteristics and prognosis. Methods The expression of EZH2 and p53 protein were detected by immunohisto-chemical method in 50 cases of breast adenosis tissues, 92 cases of breast invasive lobular carcinoma ( ILC) and 200 cases of breast in-vasive ductal carcinoma ( IDC) , and their correlation was also analyzed. Results There was no statistical significance of EZH2 be-tween ILC and IDC (P>0. 016 7), while its expression in breast adenosis tissues was lower than that in ILC and IDC (P<0. 016 7). In breast cancer the expression of EZH2 protein were not correlated with patient age, menopausal status, histological types, and pTNM stage. In contrast, its expression correlated with the tumor size, lymph node metastasis, molecular subtype, survival status and p53 (P<0. 05). There was no statistical significance of p53 between ILC and breast adenosis tissues (P>0. 016 7), while its expression in IDC was higher than that in ILC and breast adenosis tissues (P<0. 016 7). Its expression had no related to patient age, menopausal status, tumor size, lymph node metastasis in breast cancer, but related to histological types, pTNM stage, molecular subtype and sur-vival status (P<0. 05). The Kaplan-Meier survival analysis showed the expression of EZH2 and p53 had correlated with disease-free and overall survival rates of breast cancer (P<0. 05). Multivariate COX regression analysis showed that the expression of EZH2 and p53 were independent affecting factors to breast cancer patients. Conclusion The expression of EZH2 and p53 protein increase in the breast adenosis, ILC and IDC gradually, and they have positive correlation. The expression levels of EZH2 and p53 protein have im-portant value to evaluate the prognosis of breast cancer patients.
