Observation of the protective effect of N-NAC on radiation-induced pulmonary injury

VernacularTitle:N-乙酰半胱氨酸防治放射性肺损伤疗效观察
Author: Jun XIE ; Jun TANG ; Zhen YANG ; Yingru XING ; Minghong SHI ; Ming ZHU
Publication Type:Journal Article
Keywords: Radiation pneumonitis; Acetylcysteine; Transforming growth factor betal; Interleukins; Tumor necrosis factors
From: Chinese Journal of Primary Medicine and Pharmacy 2015;(z1):3-6
CountryChina
Language:Chinese
Abstract: Objective To observe the protective effect of N-NAC on radiation-induced lung injury. Methods 86 cases of thoracic neoplasm patients were chosen and randomly divided into two groups,group RT +N(n =43)and group RT(n =43).Two groups were observed by CT after radiotherapy.Acute and chronical toxicities were graded by RTOG.TGF-β1,IL-1,IL-4,TNF were observed before and after the radiotherapy.Results After 3 monthsof radiotherapy,RTOG≥2 was 23.4%(RT +N),while RTOG≥2 was 53.1%(RT).there was significant differencebetween the two groups(P <0.01).At 6,9 and 12 months,fibrosis was present in 28.4%,25.4%,22.4% receivingRT vs 58.4%,54.4%,52.4% receiving RT +N,there was significant difference between the two groups(P <0.05).TGF-β1,IL-1,IL-4,TNF were observed which showed that The RT +N were lower than RT.Conclusion N-NAC can reduce incidence rate of lung injury in radiotherapy,and can reduce the content and the release of TGF-β1,IL-1,IL-4,TNF.