Percutaneous transluminal angioplasty of lower extremity：Is preoperative use of prophylactic ;antibiotics necessary?
10.3969/j.issn.1008-794X.2015.04.006
- VernacularTitle:经皮腔内下肢血管成形术前预防性应用抗生素必要性研究
- Author:
Anhui XU
;
Jianpin QI
;
Nan WANG
- Publication Type:Journal Article
- Keywords:
antibiotic;
prophylaxis;
interventional radiology
- From:
Journal of Interventional Radiology
2015;(4):297-300
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the necessity of preoperative use of prophylactic antibiotics in percutaneous transluminal angioplasty (PTA) of lower extremity. Methods A total of 86 patients with arteriosclerosis obliterans of lower extremity (101 invalid lower extremities in total) were enrolled in this study. The patients were prospectively and randomly divided into study group (n=41, 51 limbs) and control group (n=45, 50 limbs). The patients in the study group received intravenously prophylactic antibiotics two hours before PTA, while no antibiotic was employed for the patients in the control group. The improvement of symptoms and the occurrence of infection after PTA in the two groups were compared. Results After PTA, fever was seen in 27 patients, including 12 patients of the study group (29.3%) and 15 patients of the control group (33.3%). Elevation of neutrophil count (>70%) was observed in 6 patients (14.7%) of the study group and in 7 patients (15.6%) of the control group, but the difference between the two groups was not statistically significant (P>0.05). Septicemia occurred in one patient in each group, both were aged patients with diabetes. The post-treatment infection rate in the study group and in the control group was 1.96% and 2.00%respectively, the difference between the two groups was not significant (P>0.05). Conclusion There is no significant correlation between the use of prophylactic antibiotics and the infections after PTA of lower extremity. Therefore, the clinical value of using prophylactic antibiotics for patients with high risk of infection needs to be verified by further randomized controlled trials.
